Mc3r^{tm1.1(cre)Dolsn}
Targeted Allele Detail

Summary

• Symbol: Mc3r^{tm1.1(cre)Dolsn}
• Name: melanocortin 3 receptor; targeted mutation 1.1, David P Olson
• MGI ID: MGI:6690499
• Synonyms: Mc3r^cre
• Gene: Mc3r Location: Chr2:172090412-172093034 bp, + strand Genetic Position: Chr2, 94.8 cM
• Alliance: Mc3r^{tm1.1(cre)Dolsn} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:270010
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Mc3r^{tm1.1(cre)Dolsn} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mc3r (MGI:96929)

• Mutation details: The targeting construct containing a T2A-Cre fusion cassette replaced the stop codon of the mouse Mc3r gene. The neo selection marker was excised by breeding chimeric mice to Flp deleter animals. (J:270010)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mc3r (mouse) Summary of all recombinase alleles driven by Mc3r. Comparative matrix view of recombinase activities Alliance mouse Mc3r gene page

Expression

In Mice Carrying this Mutation:

15 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mc3r Mutation: 31 strains or lines available

References

• Original: J:270010 Pei H, et al., Lateral Hypothalamic Mc3R-Expressing Neurons Modulate Locomotor Activity, Energy Expenditure, and Adiposity in Male Mice. Endocrinology. 2019 Feb 1;160(2):343-358
• All: 3 reference(s)