Gcgr^em2Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gcgr^em2Smoc
• Name: glucagon receptor; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
• MGI ID: MGI:6690504
• Synonyms: Gcgr^V369M
• Gene: Gcgr Location: Chr11:120421525-120429812 bp, + strand Genetic Position: Chr11, 84.24 cM, cytoband E2
• Alliance: Gcgr^em2Smoc page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR/Cas9 technology generated a G to A change at position 1105 (c.1105G>A) resulting in a valine to methionine substitution at amino acid 369 (p.V369M). (J:300368)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gcgr Mutation: 8 strains or lines available

References

• Original: J:300368 Lin G, et al., Characterization of a naturally occurring mutation V368M in the human glucagon receptor and its association with metabolic disorders. Biochem J. 2020 Jul 17;477(13):2581-2594
• All: 3 reference(s)