Galnt3^tm1Tok
Targeted Allele Detail

Summary

• Symbol: Galnt3^tm1Tok
• Name: polypeptide N-acetylgalactosaminyltransferase 3; targeted mutation 1, Toshihisa Komori
• MGI ID: MGI:6690609
• Synonyms: Galnt3^-
• Gene: Galnt3 Location: Chr2:65913110-65955217 bp, - strand Genetic Position: Chr2, 38.99 cM, cytoband C3
• Alliance: Galnt3^tm1Tok page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301856
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The first 150 amino acids encoded within exon 2 were replaced with an IRES-lacZ-neo cassette. Immunohistochemical analysis confirmed the absence of encoded protein in the perinuclear regions of spermatocytes and round spermatids from homozygous mutant male mice. (J:301856)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Galnt3 Mutation: 29 strains or lines available

References

• Original: J:301856 Miyazaki T, et al., Galnt3 deficiency disrupts acrosome formation and leads to oligoasthenoteratozoospermia. Histochem Cell Biol. 2013 Feb;139(2):339-54
• All: 2 reference(s)