Csnk1g2^em1Xidw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Csnk1g2^em1Xidw
• Name: casein kinase 1, gamma 2; endonuclease-mediated mutation 1, Xiaodong Wang
• MGI ID: MGI:6690844
• Synonyms: Csnk1g2^-
• Gene: Csnk1g2 Location: Chr10:80458672-80476583 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Csnk1g2^em1Xidw page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a 56bp deletion in exon 2. Immunoblot analysis confirmed the absence of protein expression in testicular extracts from homozygous mutant mice. (J:298682)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Csnk1g2 Mutation: 37 strains or lines available

References

• Original: J:298682 Li D, et al., Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3. Elife. 2020 Nov 18;9:e61564
• All: 1 reference(s)