Eaf1^tm1.1Zhow
Targeted Allele Detail

Summary

• Symbol: Eaf1^tm1.1Zhow
• Name: ELL associated factor 1; targeted mutation 1.1, Zhou Wang
• MGI ID: MGI:6690858
• Synonyms: Eaf1^fl, Eaf1^flox
• Gene: Eaf1 Location: Chr14:31217036-31231815 bp, + strand Genetic Position: Chr14, 19.14 cM, cytoband B
• Alliance: Eaf1^tm1.1Zhow page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:288972
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Using a recombineering approach, a loxP site flanked neomycin resistance gene was inserted into intron 1. An FRT site flanked neo cassette and a loxP site were inserted into intron 2. The two neo cassettes were removed through subsequent cre-mediated and flp-mediated recombination, leaving a conditional-ready allele with exon 2 floxed. (J:288972)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eaf1 Mutation: 16 strains or lines available

References

• Original: J:288972 Pascal LE, et al., Conditional Deletion of Eaf1 Induces Murine Prostatic Intraepithelial Neoplasia in Mice. Neoplasia. 2019 Aug;21(8):752-764
• All: 1 reference(s)