Trim8^em1Holi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trim8^em1Holi
• Name: tripartite motif-containing 8; endonuclease-mediated mutation 1, Hongliang Li
• MGI ID: MGI:6690866
• Synonyms: TRIM8-KO
• Gene: Trim8 Location: Chr19:46490087-46504894 bp, + strand Genetic Position: Chr19, 38.92 cM, cytoband D1
• Alliance: Trim8^em1Holi page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 1 was targeted with sgRNAs (targeting CCTGCACGTTTTCGTGGAACCGG) using CRISPR/Cas9 technology, resulting in an 8 bp (CGTTTTCG) deletion. (J:303068, J:303651)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim8 Mutation: 28 strains or lines available

References

• Original: J:303651 Chen L, et al., Tripartite Motif 8 Contributes to Pathological Cardiac Hypertrophy Through Enhancing Transforming Growth Factor beta-Activated Kinase 1-Dependent Signaling Pathways. Hypertension. 2017 Feb;69(2):249-258
• All: 2 reference(s)