Tmem74^em1Fehan
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tmem74^em1Fehan
• Name: transmembrane protein 74; endonuclease-mediated mutation 1, Feng Han
• MGI ID: MGI:6690870
• Synonyms: Tmem74^-
• Gene: Tmem74 Location: Chr15:43728042-43733432 bp, - strand Genetic Position: Chr15, 16.82 cM
• Alliance: Tmem74^em1Fehan page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Sequences TCTATCCAGCTCCCAT and AGGTGACCCGACAAGGA in exon 2 were targeted using TALEN technology, resulting in the deletion of a single A nucleotide from codon 4 (histidine CAC). Immnuoblotting confirmed the near-absence of peptide expression from this allele. (J:302698)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem74 Mutation: 29 strains or lines available

References

• Original: J:302698 Shao LX, et al., Functional coupling of Tmem74 and HCN1 channels regulates anxiety-like behavior in BLA neurons. Mol Psychiatry. 2019 Oct;24(10):1461-1477
• All: 1 reference(s)