Eef1a1^tm1Klan
Targeted Allele Detail

Summary

• Symbol: Eef1a1^tm1Klan
• Name: eukaryotic translation elongation factor 1 alpha 1; targeted mutation 1, Eric Klann
• MGI ID: MGI:6693287
• Synonyms: Eef1a1^{LSL.NS3/4.TRAP.iPKR}
• Gene: Eef1a1 Location: Chr9:78385735-78389006 bp, - strand Genetic Position: Chr9, 43.65 cM, cytoband E1
• Alliance: Eef1a1^tm1Klan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:292750
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: The targeting cassette introduced into intron 1 a floxed stop cassette, a recombinant nonstructural protein recognition site NS3/4A (allows for chemical inhibition with asunaprevir), self-cleaving 2A proteinase sequence, ribosomal localized EGFP reporter gene (EGFP/L10), self-cleaving 2A proteinase sequence, and an inducible kinase domain from an RNA-activated protein kinase (iPKR). (J:292750)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Eef1a1 Mutation: 60 strains or lines available

References

• Original: J:292750 Shrestha P, et al., Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation. Nat Neurosci. 2020 Feb;23(2):281-292
• All: 2 reference(s)