Nemp1^em1Hmc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nemp1^em1Hmc
• Name: nuclear envelope integral membrane protein 1; endonuclease-mediated mutation 1, Helen McNeill
• MGI ID: MGI:6693344
• Synonyms: Nemp1^{em#(TCP)McNeill}
• Gene: Nemp1 Location: Chr10:127512934-127536918 bp, + strand Genetic Position: Chr10, 74.6 cM
• Alliance: Nemp1^em1Hmc page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting deleted exon 3. (J:303621)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Nemp1^em1Hmc/Nemp1^em1Hmc	C57BL/6N-Nemp1^em1Hmc

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms Sex:
cellular	√
abnormal oocyte morphology	√
abnormal female meiosis	√
maternal effect	√
endocrine/exocrine glands	√
decreased primordial ovarian follicle number	√
hematopoietic system	√	√
anemia	√	√
reproductive system	√	N
reproductive system phenotype		N
abnormal oocyte morphology	√
abnormal female meiosis	√
decreased primordial ovarian follicle number	√
female infertility	√
reduced female fertility	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nemp1 Mutation: 37 strains or lines available

References

• Original: J:303621 Tsatskis Y, et al., The NEMP family supports metazoan fertility and nuclear envelope stiffness. Sci Adv. 2020;6(35):eabb4591
• All: 2 reference(s)