Layn^em2Romd
Endonuclease-mediated Allele Detail

Summary

• Symbol: Layn^em2Romd
• Name: layilin; endonuclease-mediated mutation 2, Michael D Rosenblum
• MGI ID: MGI:6693357
• Gene: Layn Location: Chr9:50966323-50988501 bp, - strand Genetic Position: Chr9, 27.79 cM
• Alliance: Layn^em2Romd page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• CRISPR/cas9 mediated recombination inserted a premature stop codon in exon 4. (J:302853)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Layn Mutation: 22 strains or lines available

References

• Original: J:302853 Mahuron KM, et al., Layilin augments integrin activation to promote antitumor immunity. J Exp Med. 2020 Sep 7;217(9)
• All: 1 reference(s)