Chd8^em1Fezh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Chd8^em1Fezh
• Name: chromodomain helicase DNA binding protein 8; endonuclease-mediated mutation 1, Feng Zhang
• MGI ID: MGI:6693434
• Synonyms: Chd8^-
• Gene: Chd8 Location: Chr14:52435608-52495237 bp, - strand Genetic Position: Chr14, 26.84 cM
• Alliance: Chd8^em1Fezh page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome ediiting technology was used to generate a 7-nucleotide deletion in exon 1 that causes a frameshift mutation. (J:250811)

Expression

In Mice Carrying this Mutation:

5 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chd8 Mutation: 107 strains or lines available

References

• Original: J:250811 Platt RJ, et al., Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits. Cell Rep. 2017 Apr 11;19(2):335-350
• All: 4 reference(s)