Hmcn2^em3Jhm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hmcn2^em3Jhm
• Name: hemicentin 2; endonuclease-mediated mutation 1, Jeffery H Miner
• MGI ID: MGI:6693473
• Synonyms: D5
• Gene: Hmcn2 Location: Chr2:31204427-31350750 bp, + strand Genetic Position: Chr2, 21.81 cM
• Alliance: Hmcn2^em3Jhm page

Mutation origin

• Strain of Origin: (C57BL/6 x CBA)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination created an 8 bp (AGCTGGAG) deletion shortly after the translation start site resulting in a frameshift mutation. (J:289396)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmcn2 Mutation: 214 strains or lines available

References

• Original: J:289396 Lin MH, et al., Mammalian hemicentin 1 is assembled into tracks in the extracellular matrix of multiple tissues. Dev Dyn. 2020 Jun;249(6):775-788
• All: 1 reference(s)