Tbc1d21^tm1.1Yhln
Targeted Allele Detail

Summary

• Symbol: Tbc1d21^tm1.1Yhln
• Name: TBC1 domain family, member 21; targeted mutation 1.1, Ying-Hung Lin
• MGI ID: MGI:6693639
• Synonyms: Tbc1d21^-
• Gene: Tbc1d21 Location: Chr9:58266987-58277738 bp, - strand Genetic Position: Chr9, 31.7 cM, cytoband C
• Alliance: Tbc1d21^tm1.1Yhln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:299845
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4. A floxed neomycin resistance cassette was inserted downstream of exon 11. Cre-mediated recombination removed exons 4 through 11 and the selection cassette. (J:299845)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbc1d21 Mutation: 24 strains or lines available

References

• Original: J:299845 Wang YY, et al., Deficiency of the Tbc1d21 gene causes male infertility with morphological abnormalities of the sperm mitochondria and flagellum in mice. PLoS Genet. 2020 Sep;16(9):e1009020
• All: 1 reference(s)