Impg1^em1Visu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Impg1^em1Visu
• Name: interphotoreceptor matrix proteoglycan 1; endonuclease-mediated mutation 1, Visvanathan Ramamurthy
• MGI ID: MGI:6693683
• Gene: Impg1 Location: Chr9:80220612-80347534 bp, - strand Genetic Position: Chr9, 43.99 cM
• Alliance: Impg1^em1Visu page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination created a 10 nucleotide deletion in exon 2 resulting in a predicted premature termination site in exon 3. Immunohistochemical analysis confirmed the absence of expression in homozygous mice. (J:288311)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Impg1 Mutation: 48 strains or lines available

References

• Original: J:288311 Salido EM, et al., Proteoglycan IMPG2 Shapes the Interphotoreceptor Matrix and Modulates Vision. J Neurosci. 2020 May 13;40(20):4059-4072
• All: 2 reference(s)