Impg2^em1Visu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Impg2^em1Visu
• Name: interphotoreceptor matrix proteoglycan 2; endonuclease-mediated mutation 1, Visvanathan Ramamurthy
• MGI ID: MGI:6693686
• Gene: Impg2 Location: Chr16:56024676-56094119 bp, + strand Genetic Position: Chr16, 33.91 cM
• Alliance: Impg2^em1Visu page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination created a 7 nucleotide deletion in exon 3 resulting in a predicted premature termination site in exon 3. Immunohistochemical analysis confirmed the absence of expression in homozygous mice. (J:288311)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Impg2 Mutation: 69 strains or lines available

References

• Original: J:288311 Salido EM, et al., Proteoglycan IMPG2 Shapes the Interphotoreceptor Matrix and Modulates Vision. J Neurosci. 2020 May 13;40(20):4059-4072
• All: 2 reference(s)