Ddx18^em1.1Shx
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ddx18^em1.1Shx
• Name: DEAD box helicase 18; endonuclease-mediated mutation 1.1, Xiaohua Shen
• MGI ID: MGI:6693739
• Gene: Ddx18 Location: Chr1:121481564-121495709 bp, - strand Genetic Position: Chr1, 52.98 cM, cytoband E2
• Alliance: Ddx18^em1.1Shx page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination introduced loxP sites flanking exon 7. Cre mediated recombination deleted the floxed region creating a 591 bp deletion. (J:287559)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddx18 Mutation: 34 strains or lines available

References

• Original: J:287559 Zhang H, et al., DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation. Cell Rep. 2020 Jan 7;30(1):81-97.e7
• All: 1 reference(s)