Dhdds^tm1.1Sjpi
Targeted Allele Detail

Summary

• Symbol: Dhdds^tm1.1Sjpi
• Name: dehydrodolichyl diphosphate synthase; targeted mutation 1.1, Steven J Pittler
• MGI ID: MGI:6693810
• Synonyms: Dhdds^flx
• Gene: Dhdds Location: Chr4:133696339-133728229 bp, - strand Genetic Position: Chr4, 66.47 cM
• Alliance: Dhdds^tm1.1Sjpi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:287362
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A KOMP targeting vector was used to introduce an FRT flanked lacZ gene, a loxP site and neo cassette and a second loxP site upstream of exon 3 and a third loxP site downstream of exon 3. Flp mediated recombination removed the lacZ and neo, leaving exon 3 floxed. (J:287362)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dhdds Mutation: 24 strains or lines available

References

• Original: J:287362 DeRamus ML, et al., Selective Ablation of Dehydrodolichyl Diphosphate Synthase in Murine Retinal Pigment Epithelium (RPE) Causes RPE Atrophy and Retinal Degeneration. Cells. 2020 Mar 21;9(3):771
• All: 2 reference(s)