Srcap^em2Zfa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Srcap^em2Zfa
• Name: Snf2-related CREBBP activator protein; endonuclease-mediated mutation 2, Zusen Fan
• MGI ID: MGI:6694084
• Gene: Srcap Location: Chr7:127111155-127160391 bp, + strand Genetic Position: Chr7, 69.56 cM
• Alliance: Srcap^em2Zfa page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 5 bp deletion (GACCT) in exon 5 resulting in a frameshift mutation. (J:303929)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srcap Mutation: 135 strains or lines available

References

• Original: J:303929 Ye B, et al., The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells. EMBO J. 2020 Jul 1;39(13):e103786
• All: 1 reference(s)