Sprn^em1Jvt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sprn^em1Jvt
• Name: shadow of prion protein; endonuclease-mediated mutation 1, JL Vilotte
• MGI ID: MGI:6694148
• Synonyms: Sprn⁰
• Gene: Sprn Location: Chr7:139730541-139734572 bp, - strand Genetic Position: Chr7, 85.17 cM
• Alliance: Sprn^em1Jvt page

Mutation origin

• Strain of Origin: FVB/NJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: ZFN-targeting of the open reading frame produced a 1 nt deletion that results in a frameshift and early premature stop codon. (J:289583)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sprn Mutation: 12 strains or lines available

References

• Original: J:289583 Passet B, et al., The Prion-like protein Shadoo is involved in mouse embryonic and mammary development and differentiation. Sci Rep. 2020 Apr 21;10(1):6765
• All: 2 reference(s)