Mir183^em1Jzb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mir183^em1Jzb
• Name: microRNA 183; endonuclease-mediated mutation 1, Zi-Bing Jin
• MGI ID: MGI:6694196
• Gene: Mir183 Location: Chr6:30169667-30169736 bp, - strand Genetic Position: Chr6, 12.52 cM
• Alliance: Mir183^em1Jzb page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination created a 53 bp deletion including the seed sequence. Quantitative RT-PCR confirmed the absence of expression in retinas from homozygous mice. (J:286612)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir183 Mutation: 2 strains or lines available

References

• Original: J:286612 Zhang CJ, et al., Ablation of Mature miR-183 Leads to Retinal Dysfunction in Mice. Invest Ophthalmol Vis Sci. 2020 Mar 9;61(3):12
• All: 1 reference(s)