Cttnbp2^em1Yph
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cttnbp2^em1Yph
• Name: cortactin binding protein 2; endonuclease-mediated mutation 1, Yi-Ping Hsueh
• MGI ID: MGI:6694204
• Synonyms: CTTNBP2^-
• Gene: Cttnbp2 Location: Chr6:18366477-18514842 bp, - strand Genetic Position: Chr6, 8.12 cM
• Alliance: Cttnbp2^em1Yph page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALEN technology was used to generate a 2 bp frameshift deletion (CT) in exon 3. Western blot analysis confirmed absence of protein in the brain. (J:300704)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cttnbp2 Mutation: 93 strains or lines available

References

• Original: J:300704 Shih PY, et al., CTTNBP2 Controls Synaptic Expression of Zinc-Related Autism-Associated Proteins and Regulates Synapse Formation and Autism-like Behaviors. Cell Rep. 2020 Jun 2;31(9):107700
• All: 1 reference(s)