Colgalt1^tm1.1Gpt
Targeted Allele Detail

Summary

• Symbol: Colgalt1^tm1.1Gpt
• Name: collagen beta(1-O)galactosyltransferase 1; targeted mutation 1, GemPharmatech, Co., Ltd
• MGI ID: MGI:6694288
• Gene: Colgalt1 Location: Chr8:72063642-72077555 bp, + strand Genetic Position: Chr8, 34.43 cM
• Alliance: Colgalt1^tm1.1Gpt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283330
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and second loxP site were inserted downstream of exon 3 via homologous recombination. Cre mediated recombination removed exons 2 and 3 and the neo cassette. Western blot analysis confirmed the absence of protein expression in homozygous embryos at E10.5. (J:283330)

Expression

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Colgalt1 Mutation: 26 strains or lines available

References

• Original: J:283330 He L, et al., Down-regulation of GLT25D1 inhibited collagen secretion and involved in liver fibrogenesis. Gene. 2020 Mar 1;729:144233
• All: 1 reference(s)