Dnah17^em2Qsh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dnah17^em2Qsh
• Name: dynein, axonemal, heavy chain 17; endonuclease-mediated mutation 2, Qinghua Shi
• MGI ID: MGI:6694909
• Synonyms: Dnah17^M
• Gene: Dnah17 Location: Chr11:117912549-118021460 bp, - strand Genetic Position: Chr11, 82.96 cM, cytoband E2
• Alliance: Dnah17^em2Qsh page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2J)F1

Mutation description

• Allele Type: Endonuclease-mediated (Hypomorph)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting induced a point mutation (G to A) that corresponds to the human variant c.G5408A associated with male infertility. (J:285088)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnah17 Mutation: 207 strains or lines available

References

• Original: J:285088 Zhang B, et al., A DNAH17 missense variant causes flagella destabilization and asthenozoospermia. J Exp Med. 2020 Feb 3;217(2)
• All: 2 reference(s)