Myh3^tm1.2Sajm
Targeted Allele Detail

Summary

• Symbol: Myh3^tm1.2Sajm
• Name: myosin, heavy polypeptide 3, skeletal muscle, embryonic; targeted mutation 1.2, Sam J Mathew
• MGI ID: MGI:6695299
• Synonyms: Myh3^Delta
• Gene: Myh3 Location: Chr11:66969126-66993112 bp, + strand Genetic Position: Chr11, 40.59 cM
• Alliance: Myh3^tm1.2Sajm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:287755
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 2 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 7. The neo cassette was removed through subsequent flp-mediated recombination and floxed exons 3-7 were deleted through cre-mediated recombination. (J:287755)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myh3 Mutation: 74 strains or lines available

References

• Original: J:287755 Agarwal M, et al., Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development. Development. 2020 Apr 6;147(7):dev184507
• All: 2 reference(s)