Ms4a4a^em1Wwz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ms4a4a^em1Wwz
• Name: membrane-spanning 4-domains, subfamily A, member 4A; endonuclease-mediated mutation 1, Wenwen Zeng
• MGI ID: MGI:6695798
• Synonyms: Ms4a4a^-
• Gene: Ms4a4a Location: Chr19:11352887-11370154 bp, + strand Genetic Position: Chr19, 8.44 cM
• Alliance: Ms4a4a^em1Wwz page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a deletion of 77 bp near the 5'-end of the coding region. qPCR analysis confirmed the absence of transcript expression in bone marrow-derived macrophages, peritoneal macrophages, and other tissues including lung, spleen, and peritoneal exudate cells. (J:296429)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ms4a4a Mutation: 14 strains or lines available

References

• Original: J:296429 Sui Y, et al., MS4A4A Regulates Arginase 1 Induction during Macrophage Polarization and Lung Inflammation in Mice. Eur J Immunol. 2020 Oct;50(10):1602-1605
• All: 1 reference(s)