Cnot8^tm1.2Tya
Targeted Allele Detail

Summary

• Symbol: Cnot8^tm1.2Tya
• Name: CCR4-NOT transcription complex, subunit 8; targeted mutation 1.2, Tadashi Yamamoto
• MGI ID: MGI:6695887
• Gene: Cnot8 Location: Chr11:57994979-58009420 bp, + strand Genetic Position: Chr11, 35.69 cM
• Alliance: Cnot8^tm1.2Tya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:304598
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A conditional allele was generated by flanking exon 3 with loxP sites. Flp-mediated recombination removed the selection cassette inserted upstream of exon 3. Cre-mediated recombination removed the floxed exon. (J:304598)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnot8 Mutation: 35 strains or lines available

References

• Original: J:304598 Mostafa D, et al., Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability. RNA Biol. 2020 Mar;17(3):403-416
• All: 2 reference(s)