Rab44^em1Rbrc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rab44^em1Rbrc
• Name: RAB44, member RAS oncogene family; endonuclease-mediated mutation 1, RIKEN BioResource Center
• MGI ID: MGI:6695900
• Gene: Rab44 Location: Chr17:29333119-29367954 bp, + strand Genetic Position: Chr17, 15.14 cM
• Alliance: Rab44^em1Rbrc page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting deleted a 32 kb genomic segment spanning 13 exons. Western blot analysis confirmed the absence of both the short and long isoforms in bone marrow-derived mast cells. (J:304506)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rab44 Mutation: 41 strains or lines available

References

• Original: J:304506 Kadowaki T, et al., The large GTPase Rab44 regulates granule exocytosis in mast cells and IgE-mediated anaphylaxis. Cell Mol Immunol. 2020 Dec;17(12):1287-1289
• All: 3 reference(s)