Gls2^em1Xen
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gls2^em1Xen
• Name: glutaminase 2 (liver, mitochondrial); endonuclease-mediated mutation 1, Taconic Biosciences
• MGI ID: MGI:6695948
• Gene: Gls2 Location: Chr10:128030504-128045873 bp, + strand Genetic Position: Chr10, 76.44 cM
• Alliance: Gls2^em1Xen page

Mutation origin

• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a deletion of exons 2-7. Western blot confirmed absence of protein in hepatocytes. (J:271619)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gls2 Mutation: 33 strains or lines available

References

• Original: J:271619 Miller RA, et al., Targeting hepatic glutaminase activity to ameliorate hyperglycemia. Nat Med. 2018 May;24(4):518-524
• All: 1 reference(s)