Tomm7^em1Yihc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tomm7^em1Yihc
• Name: translocase of outer mitochondrial membrane 7; endonuclease-mediated mutation 1, Yi-Han Chen
• MGI ID: MGI:6695994
• Synonyms: Tomm7^-
• Gene: Tomm7 Location: Chr5:24043942-24049143 bp, - strand Genetic Position: Chr5, 10.48 cM, cytoband A3
• Alliance: Tomm7^em1Yihc page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The 5' UTR (in exon 1) and intron 2 were targeted with two sgRNAs using CRISPR/Cas9 technology, resulting in a deletion. (J:285108)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tomm7 Mutation: 14 strains or lines available

References

• Original: J:285108 Shi D, et al., Endothelial Mitochondrial Preprotein Translocase Tomm7-Rac1 Signaling Axis Dominates Cerebrovascular Network Homeostasis. Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2665-2677
• All: 1 reference(s)