Rexo2^tm1.2Arte
Targeted Allele Detail

Summary

• Symbol: Rexo2^tm1.2Arte
• Name: RNA exonuclease 2; targeted mutation 1.2, TaconicArtemis
• MGI ID: MGI:6695998
• Gene: Rexo2 Location: Chr9:48379812-48391911 bp, - strand Genetic Position: Chr9, 26.42 cM
• Alliance: Rexo2^tm1.2Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:282882
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3-5 were flanked by loxP sites and a neomycin resistance cassette flanked by FRT sites and a puromycin resistance cassette flanked by F3 sites were introduced in intron 2 and intron 5, respectively. Flp-mediated recombination removed the selection markers. Exons 3-5 were deleted via cre-mediated recombination. (J:282882)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rexo2 Mutation: 23 strains or lines available

References

• Original: J:282882 Nicholls TJ, et al., Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria. Mol Cell. 2019 Dec 5;76(5):784-796.e6
• All: 1 reference(s)