Pi4kb^tm1.1Tbal
Targeted Allele Detail

Summary

• Symbol: Pi4kb^tm1.1Tbal
• Name: phosphatidylinositol 4-kinase beta; targeted mutation 1, Tamas Balla
• MGI ID: MGI:6696050
• Synonyms: PI4KB^f
• Gene: Pi4kb Location: Chr3:94882042-94914154 bp, + strand Genetic Position: Chr3, 40.74 cM
• Alliance: Pi4kb^tm1.1Tbal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:297534
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 6. A loxP and FRT-flanked neomycin resistance cassette was inserted downstream of exon 7. Flp-mediated recombination removed the selection cassette and left exons 6 and 7 floxed. (J:297534)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pi4kb Mutation: 40 strains or lines available

References

• Original: J:297534 Baba T, et al., Myelination of peripheral nerves is controlled by PI4KB through regulation of Schwann cell Golgi function. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28102-28113
• All: 1 reference(s)