Stag2^tm1.1Soga
Targeted Allele Detail

Summary

• Symbol: Stag2^tm1.1Soga
• Name: STAG2 cohesin complex component; targeted mutation 1.1, Seishi Ogawa
• MGI ID: MGI:6696175
• Synonyms: Stag2^fl
• Gene: Stag2 Location: ChrX:41238194-41366062 bp, + strand Genetic Position: ChrX, 23.19 cM, cytoband A2
• Alliance: Stag2^tm1.1Soga page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:289000
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Two loxP sites were inserted flanking exon 7, which encodes a STAG domain, and a FRT-flanked neomycin selection cassette was inserted downstream of exon 7 before the second loxP site. Flp-mediated recombination removed the selection cassette leaving exon 7 floxed. (J:289000)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stag2 Mutation: 15 strains or lines available

References

• Original: J:289000 Ochi Y, et al., Combined Cohesin-RUNX1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes. Cancer Discov. 2020 Jun;10(6):836-853
• All: 1 reference(s)