Tecpr2^em1Wei
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tecpr2^em1Wei
• Name: tectonin beta-propeller repeat containing 2; endonuclease-mediated mutation 1, Weizmann Institute of Science
• MGI ID: MGI:6696317
• Gene: Tecpr2 Location: Chr12:110855698-110938828 bp, + strand Genetic Position: Chr12, 60.86 cM
• Alliance: Tecpr2^em1Wei page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 3 and 5 deleted 19,000 bp producing a truncated protein of 45 amino acids identical to the wild-type, followed by four missense amino acids and a premature STOP codon. (J:304963)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tecpr2 Mutation: 68 strains or lines available

References

• Original: J:304963 Tamim-Yecheskel BC, et al., A tecpr2 knockout mouse exhibits age-dependent neuroaxonal dystrophy associated with autophagosome accumulation. Autophagy. 2020;Dec 10:1-14
• All: 1 reference(s)