Mkrn3^em1Rhu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mkrn3^em1Rhu
• Name: makorin, ring finger protein, 3; endonuclease-mediated mutation 1, Ronggui Hu
• MGI ID: MGI:6704950
• Gene: Mkrn3 Location: Chr7:62067341-62069887 bp, - strand Genetic Position: Chr7, 34.37 cM
• Alliance: Mkrn3^em1Rhu page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALEN technology generated a 2 bp deletion (c.276_277delGA) in the single exon. Western blot analysis of hypothalamic extracts confirmed the absence of protein in mice with the paternally inherited mutant allele. (J:305000)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mkrn3 Mutation: 26 strains or lines available

References

• Original: J:305000 Li C, et al., MKRN3 regulates the epigenetic switch of mammalian puberty via ubiquitination of MBD3. Natl Sci Rev. 2020 Mar;7(3):671-685
• All: 3 reference(s)