Cbr1^tm1.1Tmnb
Targeted Allele Detail

Summary

• Symbol: Cbr1^tm1.1Tmnb
• Name: carbonyl reductase 1; targeted mutation 1.1, Toshiya Manabe
• MGI ID: MGI:6704988
• Gene: Cbr1 Location: Chr16:93404752-93407226 bp, + strand Genetic Position: Chr16, 54.53 cM
• Alliance: Cbr1^tm1.1Tmnb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:294908
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and a FRT-flanked neomycin resistance cassette were inserted upstream from exon 1 and a second loxP site was inserted downstream of exon 2. Cre-mediated recombination excised exons 1 and 2. (J:294908)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cbr1 Mutation: 12 strains or lines available

References

• Original: J:294908 Arima-Yoshida F, et al., Impairment of spatial memory accuracy improved by Cbr1 copy number resumption and GABAB receptor-dependent enhancement of synaptic inhibition in Down syndrome model mice. Sci Rep. 2020 Aug 25;10(1):14187
• All: 1 reference(s)