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Tor1btm1.2Wtd
Targeted Allele Detail
Summary
Symbol: Tor1btm1.2Wtd
Name: torsin family 1, member B; targeted mutation 1.2, William T Dauer
MGI ID: MGI:6705130
Synonyms: Tor1bflx
Gene: Tor1b  Location: Chr2:30842971-30849027 bp, + strand  Genetic Position: Chr2, 21.76 cM, cytoband B
Alliance: Tor1btm1.2Wtd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:288753
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  (129/Sv x C57BL/6)F1
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsThe targeting construct is designed to insert a loxP site, followed by a FRT-flanked neomycin resistance cassette, in opposite orientation to the gene, upstream of exon 3. A second loxP site was inserted just downstream of the coding region in exon 5. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:288753)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tor1b Mutation:  20 strains or lines available
References
Original:  J:288753 Li J, et al., TorsinB overexpression prevents abnormal twisting in DYT1 dystonia mouse models. Elife. 2020 Mar 23;9:e54285
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory