Tor1b^tm1.1Wtd
Targeted Allele Detail

Summary

• Symbol: Tor1b^tm1.1Wtd
• Name: torsin family 1, member B; targeted mutation 1.1, William T Dauer
• MGI ID: MGI:6705131
• Synonyms: Tor1b^-
• Gene: Tor1b Location: Chr2:30842971-30849027 bp, + strand Genetic Position: Chr2, 21.76 cM, cytoband B
• Alliance: Tor1b^tm1.1Wtd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:288753
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129/Sv x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The loxP-flanked exons 3-5 were removed via cre-mediated recombination. (J:288753)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tor1b Mutation: 20 strains or lines available

References

• Original: J:288753 Li J, et al., TorsinB overexpression prevents abnormal twisting in DYT1 dystonia mouse models. Elife. 2020 Mar 23;9:e54285
• All: 1 reference(s)