Gt(ROSA)26Sor^{em1(Tor1b)Wtd}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em1(Tor1b)Wtd}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, William T Dauer
• MGI ID: MGI:6710954
• Synonyms: B-OE
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em1(Tor1b)Wtd} page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: CRISPR/Extreme genome editing technology knocked-in the Tor1b cDNA that is preceded by a floxed stop cassette into the locus. Tor1b is expressed after cre-mediated deletion of the stop cassette. (J:288753)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:288753 Li J, et al., TorsinB overexpression prevents abnormal twisting in DYT1 dystonia mouse models. Elife. 2020 Mar 23;9:e54285
• All: 1 reference(s)