Fgf15^{tm1.1(cre)Thor}
Targeted Allele Detail

Summary

• Symbol: Fgf15^{tm1.1(cre)Thor}
• Name: fibroblast growth factor 15; targeted mutation 1.1, Bernard Thorens
• MGI ID: MGI:6711269
• Synonyms: Fgf15^CretdT
• Gene: Fgf15 Location: Chr7:144450269-144454690 bp, + strand Genetic Position: Chr7, 88.92 cM
• Alliance: Fgf15^{tm1.1(cre)Thor} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:305713
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Recombinase, Reporter)
• Mutation: Insertion
• Fgf15^{tm1.1(cre)Thor} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Fgf15 (MGI:1096383)

• Mutation details: A T2A-cre-T2A-tdTomato cassette was introduced just before the stop codon in exon 3 of the mouse Fgf15 gene via homologous recombination in embryonic stem (ES) cells. An FRT-flanked PGK-neomycin cassette located 3' of the stop codon was excised through crosses with Flp recombinase-expressing mice. (J:305713)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Fgf15 (mouse) Summary of all recombinase alleles driven by Fgf15. Comparative matrix view of recombinase activities Alliance mouse Fgf15 gene page

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgf15 Mutation: 15 strains or lines available

References

• Original: J:305713 Picard A, et al., Fgf15 neurons of the dorsomedial hypothalamus control glucagon secretion and hepatic gluconeogenesis. Diabetes. 2021 Apr 21
• All: 1 reference(s)