Mmrn2^tm1Monm
Targeted Allele Detail

Summary

• Symbol: Mmrn2^tm1Monm
• Name: multimerin 2; targeted mutation 1, Maurizio Mongiat
• MGI ID: MGI:6711429
• Gene: Mmrn2 Location: Chr14:34097461-34126244 bp, + strand Genetic Position: Chr14, 20.81 cM
• Alliance: Mmrn2^tm1Monm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:298039
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic region including all of exon 1 was replaced with a pgk-neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in homozygous mice. (J:298039)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mmrn2 Mutation: 54 strains or lines available

References

• Original: J:298039 Pellicani R, et al., Multimerin-2 maintains vascular stability and permeability. Matrix Biol. 2020 May;87:11-25
• All: 1 reference(s)