Prss50^em1Cajj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Prss50^em1Cajj
• Name: serine protease 50; endonuclease-mediated mutation 1, Carolina J Jorgez
• MGI ID: MGI:6711590
• Gene: Prss50 Location: Chr9:110687035-110693697 bp, + strand Genetic Position: Chr9, 60.79 cM
• Alliance: Prss50^em1Cajj page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting introduced a frame shift in exon 2 that produced a premature stop codon. Western blot analysis confirmed the absence of protein in the testis. (J:305434)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prss50 Mutation: 27 strains or lines available

References

• Original: J:305434 Scovell JM, et al., PRSS50 is a testis protease responsible for proper sperm tail formation and function. Development. 2021 Apr 15;148(8):dev197558
• All: 1 reference(s)