Arhgef3^em1Chej
Endonuclease-mediated Allele Detail

Summary

• Symbol: Arhgef3^em1Chej
• Name: Rho guanine nucleotide exchange factor 3; endonuclease-mediated mutation 1, Jie Chen
• MGI ID: MGI:6712019
• Gene: Arhgef3 Location: Chr14:26836856-27125868 bp, + strand Genetic Position: Chr14, 16.09 cM
• Alliance: Arhgef3^em1Chej page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALEN mediated recombination created a 17 bp deletion in exon 3 resulting in a frameshift mutation and premature stop codons. Transcript levels are reduced in muscle tissue from homozygous mice and these transcripts are predicted to produce a protein consisting of only a small portion of the N terminus. (J:304135)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgef3 Mutation: 96 strains or lines available

References

• Original: J:304135 You JS, et al., ARHGEF3 Regulates Skeletal Muscle Regeneration and Strength through Autophagy. Cell Rep. 2021 Jan 5;34(1):108594
• All: 2 reference(s)