Angptl7^em1Pli
Endonuclease-mediated Allele Detail

Summary

• Symbol: Angptl7^em1Pli
• Name: angiopoietin-like 7; endonuclease-mediated mutation 1, Peng Li
• MGI ID: MGI:6712191
• Gene: Angptl7 Location: Chr4:148579737-148584919 bp, - strand Genetic Position: Chr4, 78.76 cM
• Alliance: Angptl7^em1Pli page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: TALEN mediated recombination inserted a splice acceptor site, Venus reporter gene, and pgk-puromycin resistance cassette in exon 1. RT-PCR and western blot analysis confirmed the absence of expression in bone marrow from homozygous mice. (J:301766)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Angptl7^em1Pli/Angptl7^em1Pli	Not Specified

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
hematopoietic system	√
decreased granulocyte monocyte progenitor cell number	√
decreased hematopoietic stem cell number	√
abnormal fetal liver hematopoietic progenitor cell morphology	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Angptl7 Mutation: 27 strains or lines available

References

• Original: J:301766 Xiao Y, et al., Loss of Angiopoietin-like 7 diminishes the regeneration capacity of hematopoietic stem and progenitor cells. J Hematol Oncol. 2015 Feb 6;8:7
• All: 1 reference(s)