Tg(Nanog-cre/Esr1*)4470Mms
Transgene Detail

Summary

• Symbol: Tg(Nanog-cre/Esr1*)4470Mms
• Name: transgene insertion 4470, Michael Shen
• MGI ID: MGI:6714092
• Synonyms: Tg(Nanog-cre/ERT2)4470Mms
• Transgene: Tg(Nanog-cre/Esr1*)4470Mms Location: unknown
• Alliance: Tg(Nanog-cre/Esr1*)4470Mms page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Nanog-cre/Esr1*)4470Mms expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nanog (MGI:1919200)

• Mutation details: The bacterial artificial chromosome, RP23-406B15, containing Nanog and its regulatory sequences was modified to insert a cDNA encoding Cre/Esr1* fusion protein into the translation initiation start site. Additional sequencing indicates that the fusion is not ERT2, but appears to be a mutant derivative of the mouse estrogen receptor. (J:248397)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nanog (mouse) Summary of all recombinase alleles driven by Nanog. Comparative matrix view of recombinase activities Alliance mouse Nanog gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:248397 Talos F, et al., A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue. Nat Commun. 2017 Apr 21;8:14662
• All: 1 reference(s)