Acp4^em1Jcch
Endonuclease-mediated Allele Detail

Summary

• Symbol: Acp4^em1Jcch
• Name: acid phosphatase 4; endonuclease-mediated mutation 1, Jan Hu
• MGI ID: MGI:6715233
• Synonyms: Acp4^R110C
• Gene: Acp4 Location: Chr7:43901572-43906802 bp, - strand Genetic Position: Chr7, 28.77 cM
• Alliance: Acp4^em1Jcch page

Mutation origin

• Strain of Origin: (C57BL/6N x SJL)F1 x C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting introduced the mutation responsible for the amino acid substitution of arginine with cysteine at position 110 (R110C). (J:332462)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Acp4 Mutation: 16 strains or lines available

References

• Original: J:332462 Liang T, et al., Enamel defects in Acp4(R110C/R110C) mice and human ACP4 mutations. Sci Rep. 2022 Oct 1;12(1):16477
• All: 2 reference(s)