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Dhcr24tm1c(EUCOMM)Wtsi
Targeted Allele Detail
Summary
Symbol: Dhcr24tm1c(EUCOMM)Wtsi
Name: 24-dehydrocholesterol reductase; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:6715348
Synonyms: Dhcr24flx
Gene: Dhcr24  Location: Chr4:106418279-106446310 bp, + strand  Genetic Position: Chr4, 49.67 cM, cytoband C7
Alliance: Dhcr24tm1c(EUCOMM)Wtsi page
IMPC: Dhcr24 gene page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:304449
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsThe L1L2_st0 cassette was inserted at position 106428382 of Chromosome 4 upstream of the critical exon 3 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon 3 at position 106429001. The critical exon 3 is thus flanked by loxP sites. A "conditional ready" (floxed) allele is created by flp recombinase expression in mice carrying this allele. (J:304449)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dhcr24 Mutation:  35 strains or lines available
References
Original:  J:304449 Kanuri B, et al., Generation and validation of a conditional knockout mouse model for desmosterolosis. J Lipid Res. 2021 Jan 30;62:100028
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory