Dhcr24tm1c(EUCOMM)Wtsi
Targeted Allele Detail
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Symbol: |
Dhcr24tm1c(EUCOMM)Wtsi |
Name: |
24-dehydrocholesterol reductase; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:6715348 |
Synonyms: |
Dhcr24flx |
Gene: |
Dhcr24 Location: Chr4:106418279-106446310 bp, + strand Genetic Position: Chr4, 49.67 cM, cytoband C7
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Alliance: |
Dhcr24tm1c(EUCOMM)Wtsi page
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IMPC: |
Dhcr24 gene page |
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Germline Transmission: |
Earliest citation of germline transmission:
J:304449
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Parent Cell Line: |
JM8.F6 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
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Mutation details: The L1L2_st0 cassette was inserted at position 106428382 of Chromosome 4 upstream of the critical exon 3 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon 3 at position 106429001. The critical exon 3 is thus flanked by loxP sites. A "conditional ready" (floxed) allele is created by flp recombinase expression in mice carrying this allele.
(J:304449)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Dhcr24 Mutation: |
35 strains or lines available
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Original: |
J:304449 Kanuri B, et al., Generation and validation of a conditional knockout mouse model for desmosterolosis. J Lipid Res. 2021 Jan 30;62:100028 |
All: |
2 reference(s) |
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