Rac3^tm1.1Bea
Targeted Allele Detail

Summary

• Symbol: Rac3^tm1.1Bea
• Name: Rac family small GTPase 3; targeted mutation 1.1, The Beatson Institute for Cancer Research
• MGI ID: MGI:6715570
• Synonyms: Rac1b^fl
• Gene: Rac3 Location: Chr11:120612296-120614795 bp, + strand Genetic Position: Chr11, 84.46 cM
• Alliance: Rac3^tm1.1Bea page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306088
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An F3 site flanked neomycin resistance gene cassette and a loxP site were inserted into intron 3 and an FRT site flanked hygromycin resistance gene cassette and a second loxP site were inserted into intron 4. The neo and hygro cassettes were removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exon 4 floxed. (J:306088)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rac3 Mutation: 13 strains or lines available

References

• Original: J:306088 Gudino V, et al., RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways. Nat Commun. 2021 Apr 20;12(1):2335
• All: 1 reference(s)