Yap1^tm1.1Hmc
Targeted Allele Detail

Summary

• Symbol: Yap1^tm1.1Hmc
• Name: yes-associated protein 1; targeted mutation 1.1, Helen McNeill
• MGI ID: MGI:6716871
• Gene: Yap1 Location: Chr9:7932000-8004597 bp, - strand Genetic Position: Chr9, 2.46 cM
• Alliance: Yap1^tm1.1Hmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:304126
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT flanked splice acceptor-IRES-betageo cassette and loxP site were inserted in intron 1 and a loxP site was inserted in intron 2 via homologous recombination. Cre-mediated recombination deleted exon 2. (J:195266, J:304126)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Yap1 Mutation: 38 strains or lines available

References

• Original: J:304126 Masson C, et al., Yap haploinsufficiency leads to Muller cell dysfunction and late-onset cone dystrophy. Cell Death Dis. 2020 Aug 14;11(8):631
• All: 2 reference(s)