Nr4a3^em1Juz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nr4a3^em1Juz
• Name: nuclear receptor subfamily 4, group A, member 3; endonuclease-mediated mutation 1, Julie Zikherman
• MGI ID: MGI:6717373
• Gene: Nr4a3 Location: Chr4:48045153-48086447 bp, + strand Genetic Position: Chr4, 26.07 cM, cytoband B2
• Alliance: Nr4a3^em1Juz page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 3, which contains the ATG start codon, was targeted with gRNA using CRISPR/Cas9 technology in zygotes containing the Nr4a1^tm1Pcn allele, resulting in a 115 bp deletion. This allele represents founder line 2. (J:306652)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr4a3 Mutation: 54 strains or lines available

References

• Original: J:306652 Tan C, et al., NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting. Nat Immunol. 2020 Oct;21(10):1267-1279
• All: 1 reference(s)