Grem1^{tm1.1(cre/ERT2)Snjt}
Targeted Allele Detail

Summary

• Symbol: Grem1^{tm1.1(cre/ERT2)Snjt}
• Name: gremlin 1, DAN family BMP antagonist; targeted mutation 1.1, Shannon J Turley
• MGI ID: MGI:6718253
• Synonyms: Grem1-CreER^T2
• Gene: Grem1 Location: Chr2:113579020-113588993 bp, - strand Genetic Position: Chr2, 57.43 cM
• Alliance: Grem1^{tm1.1(cre/ERT2)Snjt} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:305302
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Grem1^{tm1.1(cre/ERT2)Snjt} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Grem1 (MGI:1344337)

• Mutation details: The targeting construct introduced in exon2 after ATG, CreERT2-SV40-FRT-pgk-neo-FRT. Flp-mediated recombination removed the selection cassette. (J:305302)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Grem1 (mouse) Summary of all recombinase alleles driven by Grem1. Comparative matrix view of recombinase activities Alliance mouse Grem1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grem1 Mutation: 19 strains or lines available

References

• Original: J:305302 Kapoor VN, et al., Gremlin 1(+) fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues. Nat Immunol. 2021 May;22(5):571-585
• All: 2 reference(s)